智能植介入诊疗器械的交叉创新与转化

（1）医用材料改性与临床应用

（2）血管介入创新研究及转化

（3）组织稳态修复以及干细胞

（4）起搏器研究以及神经调控

（5）超微创手术智能操作系统

Cross-disciplinary innovation and translation of intelligent implantable interventional diagnostic and therapeutic devices

（1）Modification and clinical application of medical materials

（2）Innovative research and translation of vascular intervention

（3）Tissue homeostasis repair and stem cells

（4）Pacemaker research and neural regulation

（5）Intelligent operating system for ultra-minimally invasive surgery

第十三届、第十四届全国人大代表

生物医用材料改性技术国家地方联合工程实验室主任

中国医工交叉与转化协同创新平台理事长

beat365在线唯一官网 教授

beat365在线唯一官网附属第十人民医院微创与介入医学研究中心主任

Director of the National-Local Joint Engineering Laboratory for Biomedical Material Modification Technology

Chairman of China's Collaborative Innovation Platform for Medical-Industrial Interdisciplinary Integration and Translation

Professor, Tongji University School of Medicine

Director of the Minimally Invasive and Interventional Medicine Research Center, Tenth People's Hospital of Tongji University

二级教授、入选国家万人计划领军人才，中国科学院有效候选人。享受国务院特殊津贴，获全国五一劳动奖章、泰山学者特聘专家、有突出贡献中青年专家等称号。

长期从事医工交叉与智慧医学相关研究，将材料科学、医学、信息科学等前沿技术与医疗器械创新交叉结合，在医用材料改性、血管植介入、组织稳态修复、干细胞治疗、无线起搏器、神经调控、超微创手术系统等领域取得系列成果。

在血管通路领域，研制国际首台心电彩超多普勒系统及导管，解决靶血管智能筛选、无盲区穿刺、生物电导航等国际难题。在心脑血管领域，发明非对称药物涂层技术；首创超声控释药物球囊，药物利用度大幅度提高；发明可降解锌铜合金支架，选择强韧度、降解时间等性能符合临床需求的锌合金支架，国际上首次揭示锌合金支架体内降解规律，率先应用于临床。在生物电节律领域，突破大容量植入器械电池、超低功耗起搏器芯片、精准输送系统等关键技术，研发了兼具超长服役寿命和多模态感知的新一代无线心脏起搏器。

以第一完成人获国家科技进步二等奖、何梁何利科学与技术创新奖、谈家桢生命科学奖、教育部技术发明一等奖、省技术发明一等奖、中国产学研创新成果一等奖、中国专利优秀奖等国家和省部级奖励。

组建国家地方联合工程实验室1个、省部级创新平台6个。主持国家自然科学基金、国家“十二五”科技支撑、“十三五”“十四五”重点研发、高技术产业化、强基工程等国家级和省部级项目30余项；发表论文200余篇(SCI收录 116 篇)，申请国内外专利370余项，已获授权近200项，其中国际专利18项；成果转化取得中国医疗器械注册证 71件、欧洲注册证5件；参与起草国家和行业标准12项；成果被中国和欧美临床诊疗指南/专家共识收录5项；培养博士后、博士、硕士近百人。

A second-level professor, he was selected as a Leading Talent of the National Ten Thousand Talents Program and a valid candidate for the Chinese Academy of Sciences. He is a recipient of the Special Government Allowance of the State Council, and has been honored with titles including the National May 1st Labor Medal, "Taishan Scholar" Distinguished Expert, and "Outstanding Middle-aged and Young Expert with Remarkable Contributions".

He has long been engaged in research on the integration of medicine and engineering, as well as smart medicine, integrating cutting-edge technologies in materials science, medicine, and information science with innovations in medical devices. This has yielded a series of achievements in fields such as medical material modification, vascular implantation and intervention, tissue homeostasis repair, stem cell therapy, wireless pacemakers, neural regulation, and ultra-minimally invasive surgical systems.

In the field of vascular access, he have developed the world's first electrocardiographic color Doppler ultrasound system and catheter, addressing international challenges such as intelligent screening of target vessels, puncture without blind spots, and bioelectrical navigation. In the field of cardiovascular and cerebrovascular diseases, he have invented asymmetric drug coating technology; pioneered ultrasound-controlled drug-releasing balloons, significantly improving drug utilization; and invented degradable zinc-copper alloy stents, selecting zinc alloy stents with properties such as strength, toughness, and degradation time that meet clinical needs. He are the first to reveal the degradation pattern of zinc alloy stents in vivo internationally and have taken the lead in their clinical application. In the field of bioelectrical rhythm, he have made breakthroughs in key technologies such as high-capacity implantable device batteries, ultra-low power pacemaker chips, and precise delivery systems, developing a new generation of wireless cardiac pacemakers with both ultra-long service life and multi-modal sensing capabilities.

As the first principal investigator, he has received the National Science and Technology Progress Award (Second Class), Ho Leung Ho Lee Award for Science and Technology Innovation, Tan Jiazhen Life Science Award, First Class Technical Invention Award of the Ministry of Education, Provincial First Class Technical Invention Award, First Prize of China Industry-University-Research Innovation Achievements, and China Patent Excellence Award, among other national and provincial honors.

He has established one National-Local Joint Engineering Laboratory and six provincial/ministerial innovation platforms. He has presided over over 30 national and provincial projects, including the National Natural Science Foundation of China, the National "Twelfth Five-Year" Science and Technology Support Program, key research and development projects during the "Thirteenth Five-Year" and "Fourteenth Five-Year" periods, high-tech industrialization projects, and foundational projects.He has published over 200 papers (116 indexed in SCI), filed more than 370 domestic and interna tional patent applications, and been granted nearly 200 patents (including 18 international patents). The achievements have been translated into 71 Chinese medical device registration certificates and 5 European registration certificates. I have participated in drafting 12 national and industry standards. His research findings have been included in 5 clinical diagnosis and treatment guidelines/expert consensuses in China, Europe, and the United States. He has supervised nearly 100 postdoctoral fellows, doctoral students, and master's students.